NFL Network Insider Ian Rapoport reported that the early indication is Williams' ACL was spared in the injury. If an MRI confirms the initial diagnosis, the defensive tackle could return this season.
Williams left Friday night's preseason game against the Cleveland Browns after injuring his knee early in the second quarter.
The heart-and-soul of the Bills defense, getting Williams back on the field at any stage would be a boost to Sean McDermott's squad.
The 35-year-old people-mover played 31 regular-season games the past two seasons. In 2017 he compiled 41 tackles and three sacks to go along with two passes defended.
Here are other injuries we're tracking around the league:
- Chicago Bears linebacker Leonard Floydsuffered a hand injury during the first half against the Denver Broncos and left the game. Tight end Adam Shaheen suffered an ankle injury during the opening minutes and was carted from the sideline to the locker room. Bears coach Matt Nagy said after the game he didn't believe Floyd or Shaheen suffered fractures, but the pair will undergo further testing Sunday.
- Several Minnesota Vikings departed Saturday's game against the Jacksonville Jaguars with injuries. Mackensie Alexander (ankle), defensive end Ade Aruna (knee) and offensive lineman Josh Andrews (ankle) left and did not return. NFL Network's Tom Pelissero reported X-rays on Alexander's ankle are negative and the team's inital diagnosis is an ankle sprain. Alexander will undergo an MRI on Sunday.
Additionally, coach Mike Zimmer said offensive lineman Cedric Lang will land on injured reserve while offensive tackle Mike Remmers should return next week. Center Pat Elflein has a chance to return soon as well.
Cowboys safety Xavier Woods made an early exit after suffering a hamstring injury. Cowboys running back Bo Scarbrough suffered a hip injury in the second half and defensive tackle Datone Jones left in the third quarter with a knee injury. Safety Jameill Showers was helped off the sideline and into the locker room after suffering an undisclosed injury.