Darnold missed practice all week while dealing with a foot injury.
The No. 3 overall pick injured his foot in a Week 9 loss to the Miami Dolphins and missed a Week 10 tilt. Despite optimism that the injury wouldn't linger past the team's bye week, Darnold will miss the second game of his rookie campaign.
The first-round pick has struggled through growing pains in his rookie season, completing just 55 percent of his passes for 214.9 yards per game with 14 interceptions to 11 touchdowns and a 68.3 passer rating, worst in the NFL.
Check back next week to see if the rookie can return for December.