NFL Network Insider Ian Rapoport reports that Seferian-Jenkins is taking a step away for a month for personal reasons, and the team will cut him as he sorts through that process.
It remains to be seen whether he could re-sign in New England or elsewhere later this offseason.
ASJ was not at Tuesday's mandatory minicamp practice.
The Patriotssigned the tight end to a one-year, vet-minimum contract on April 10. The deal included a $50,000 signing bonus.
Cutting Seferian-Jenkins leaves the Patriots tight end room with Benjamin Watson (suspended to open the season), Matt LaCosse, Ryan Izzo, Stephen Anderson and Andrew Beck. ASJ appeared slated to be a flex TE used as a pass-catcher as the Pats work piecemeal to replace the gaping hole left by Rob Gronkowski's retirement.