The Chiefs have placed the running back on injured reserve, NFL Network Insider Ian Rapoport reported, per a source. Charles needs a second surgery on his ailing knee, though the severity of his injury remains unclear.
The earliest Charles can return is Kansas City's Week 17 game against the Chargers, a game that could very well decide playoff seeding and/or the champion of the wild AFC West. The running back, if healthy, would then be available for a postseason run.
Tuesday's news is the latest in a string of setbacks for Charles, who has yet to fully recover from his second ACL tear suffered last season. Charles returned to the field in Week 5, but never regained the starting tailback role from Spencer Ware. The veteran back ran for just 40 yards on 12 carries in three games this season.
Charles obviously did not receive good news.
Rapoport reported Charles' knee surgery on Wednesday went well as expected, and because of that, the running back has a shot to return later this season.
Charles' career has taken an unfortunate turn. One of the most dynamic running backs in the league will now be sidelined for the better part of two seasons with knee trouble. And while the Chiefs will move steadily along with Ware and West in the backfield, Charles' future with the team remains in doubt.