Wharton will announce his retirement in a press conference at Panthers training camp on Tuesday.
Now 33 years old, Wharton started 111 of 115 games, seeing time at left tackle in addition to guard. Although he spent the 2012 season on the Bengals' injury list, he never suited up for any team other than the Panthers.
Wharton had been deliberating since February, which gave general manager Dave Gettlement a chance to add depth on the interior of his offensive line.
That guard pairing at least has early-round pedigrees, which is more than can be said for the tackles. Nate Chandler is a converted defensive end, and Byron Bell has been a liability on the right side.
Although the revamped wide receiver corps was a national talking point all offseason, the offensive line is a bigger concern leading up to the 2014 season.