Culliver saw plenty of playing time last season when the opposition was in three- and four wide receiver sets. His misfortune likely locks up a roster spot for Nnamdi Asomugha, who had been firmly on the bubble.
Meanwhile, the law of averages appears to be catching up to the Niners, who had managed to avoid serious injuries during Harbaugh's first two seasons at the helm.
More Cooper fallout
McCoy said the situation hurts because it's like "losing a friend ... I can't respect a guy like that."
Hopin' on Harvin
"We don't have any dates or timeline," Carroll said, "but we'll be optimistic and hope he'll get back as soon as possible and be ready to go, eventually."
Carroll's choice of words tells us Harvin's return in 2013 is far from guaranteed.
Quote of the day
We close with a complete list of active quarterbacks who are superior to Alex Smith: Tom Brady, Joe Flacco, Ben Roethlisberger, Andrew Luck, Peyton Manning, Philip Rivers, Michael Vick, Robert Griffin III, Eli Manning, Tony Romo (the whole NFC East!), Jay Cutler, Aaron Rodgers, Matthew Stafford, Matt Ryan, Cam Newton, Drew Brees, Russell Wilson and Colin Kaepernick.