The Colts' receiver, who had been battling a sprained foot all week, was listed as active by the team.
Hilton, the Colts' top pass-catcher has 38 receptions on 81 targets, compiling 621 yards and three touchdowns.
New offensive coordinator Rob Chudzinski, taking over for a fired Pep Hamilton, already has a tough task facing the NFL's No. 1 defense. Having Hilton on the field will certainly make things a little easier for him.