The NFL's leading rusher is dealing with a back injury.
McCaffrey leads the NFL in rushing yards (587) and scrimmage yards (866). His 866 scrimmage yards are the second-most through a team's first five games of a season since 1950 -- only Jim Brown (988 in the first five games in 1963) had more.
With a long flight to London on tap for the Panthers on Wednesday night, it makes sense for the team to give the running back rest. Barring an unforeseen setback, it would be a surprise if Carolina's best player doesn't play Sunday against Tampa Bay -- the only team that has slowed McCaffrey this season, holding him to 53 scrimmage yards in Week 2.