It was over when ...
Peyton Manning's 5-yard touchdown pass to Reggie Wayne gave the Colts a 31-27 lead with 1:54 remaining, completing a rally in which Indianapolis scored 21 points in just over two minutes.
Game ball
Colts LB Gary Brackett's 68-yard touchdown off the first of Sage Rosenfels' three fourth-quarter turnovers effectively turned the momentum around. Raheem Brock teamed up with CB Marlin Jackson on a vicious hit that sent Rosenfels spinning through the air as he lost the football.
Key stat
Rosenfels played error-free through three quarters before struggling with ball security down the stretch. He got Houston out to a 17-point lead but lost two fumbles and threw an interception, which led to one of the biggest collapses in Texans history.
Noteworthy
Rosenfels started in place of Matt Schaub, who was sent to the hospital with an intestinal infection on Saturday night. ... Commissioner Roger Goodell was in attendance for the Texans' home opener, delayed due to Hurricane Ike. ... Texans WR Andre Johnson recorded a season-high 131 yards on nine receptions.