Nine weeks in the books, eight more to go! We’re on to Week 10 … and it’s packed with storylines. To better understand and decipher them, NFL Pro has a wealth of data and insights, carefully curated to highlight what matters most in each game. And in the world of fantasy football, we need every advantage we can get.
Here are four of those storylines, with all the relevant NFL Pro insights and the fantasy fallout we can expect this weekend.
Drake London against Sauce Gardner and the upgraded Colts secondary
On the whole, the Atlanta passing attack has struggled to get off the ground this season. They rank 26th in NFL Pro’s overall offensive passing efficiency and have just eight touchdown passes on the season, third-fewest in the league … behind the Browns and Titans. The one bright spot has been wide receiver Drake London. Since getting healthy (from a season-opening shoulder injury) around Week 4, London has averaged 25.95 fantasy points per game — most among wide receivers — scoring 25+ points in three of four games played over that span. His 32.2% target rate trails only Jaxon Smith-Njigba and Puka Nacua on the season (min. 100 routes run) and he’s averaged an elite 3.1 yards per route run since that Week 4 turnaround.
Early on Sunday, London and the Falcons will take on the Colts in Berlin … potentially the debut of freshly acquired All-Pro cornerback Sauce Gardner, if he clears concussion protocol. In a somewhat inconsistent first half with the Jets, Gardner has faced his opponent’s number one receiver on 45.5% of his coverage matchups, the second-highest rate in the NFL (min. 100 coverage matchups). And when targeted, Gardner has forced a tight window (less than one yard of separation) at a 53.8% rate, which also leads the league (min. 10 targets). Before his arrival, the Colts were allowing just 11.2 yards per reception to wide receivers (fourth-fewest) but 158.5 yards per game (ninth-most), as they’d faced a league-high 348 pass attempts while putting opponents in come-from-behind mode early and often. This has all the makings of another double-digit target day for London, and could result in a must-watch duel between him and Gardner if the corner is healthy.
Fantasy Fallout: You’re absolutely starting Drake London, no matter the matchup, and can expect quite a few passes from Michael Penix Jr. against Indy, which makes him a streaming candidate as well.
The Bucs pass rush strive to slow down MVP candidate Drake Maye
Coming off their Week 9 bye, the Buccaneers pass rush is fresh and fierce, ranking fourth in pressure rate and 10th in sack rate so far in 2025. They’ve done it largely with extra pass rushers, as Todd Bowles has blitzed at the seventh-highest rate in the league through nine weeks. And now they’ll meet with Drake Maye and a highly suspect Patriots offensive line. While Tampa Bay has posted the fourth-highest pressure rate on defense, New England has surrendered the fourth-highest pressure rate on offense.
However, Maye has been a wizard under duress: New England sports NFL Pro’s seventh-most efficient passing offense under pressure and ranks fourth specifically against the blitz. The second-year QB has seven touchdowns, zero interceptions and a 125.6 passer rating against the blitz (that passer rating is second-best among qualified passers), and he leads all passers with 8.5 yards per attempt under pressure. Additionally, Maye has the Patriots ranked number one in NFL Pro efficiency on deep passes — where he’s completed 15 of 22 attempts for five touchdowns, zero interceptions and a 150.6 passer rating. On the other side, the Bucs rank fourth in defensive efficiency on deep passes and have allowed one TD, logged one INT and held passers to a 23.3% completion rate on those attempts. This is a good-against-good matchup across the board.
Fantasy Fallout: Like the other Drake above (London), Maye is a must-start for fantasy. But considering Tampa Bay’s strengths at rushing the passer and defending the deep ball, as well as Kayshon Boutte's hamstring injury, this might be a particularly big day for Stefon Diggs (and Hunter Henry to a lesser degree) underneath.
Matthew Stafford & Davante Adams against the Niners red-zone defense
The current NFL leader in passing touchdowns isn’t Patrick Mahomes, Aaron Rodgers or even Drake Maye … it’s Matthew Stafford. Unsurprisingly, Stafford has been lights out in the red zone this season, with 17 touchdowns and zero interceptions on 55 red zone pass attempts (second only to Mahomes). His primary weapon in that area has been Davante Adams, who leads the NFL with eight receiving touchdowns and snagged seven of them on red zone plays, thanks in large part to a monstrous 37.0% target rate in that area.
Their opponent in Week 10, the 49ers, is not likely to put a stop to the Stafford-Adams machine. San Francisco has allowed the second-highest passer rating on red zone passes (124.7) with a 75.0% completion rate, resulting in 11 touchdowns on 32 attempts. They’ve allowed a 9.2% completion rate over expected on those throws, fifth-highest in football. And you don’t have to look far for a highly specific example: Stafford tagged this defense for three touchdowns just five weeks ago, all on red zone plays, without Adams scoring (Kyren Williams caught two, Puka Nacua caught one). The Niners have allowed multiple pass TDs to four of the last five QBs they’ve faced (Michael Penix Jr. had just one). One of the major components of their struggle: they pressure the quarterback on just 20.6% of red zone dropbacks, fourth-least in the NFL. Stafford has a 117.1 passer rating and averages 0.34 EPA/dropback when he’s not pressured, and he was kept clean on all three touchdowns against San Fran in Week 5.
Fantasy Fallout: Both Stafford and Nacua are absolute must-start plays and could each push to finish atop their position this week. They’re also an excellent stack in DFS contests. Roll them out everywhere you can.
The Packers on play action against Philly’s front … plus Jaelan Phillips
So far this season, the Packers have run play action on 29.8% of dropbacks, the fifth-highest rate in the league. On those play-action dropbacks, they’re NFL Pro’s fifth-most efficient passing offense, with a +6.8 completion percentage over expected and 0.26 EPA/dropback (sixth-highest in the NFL). Jordan Love has thrown five touchdowns and one interception on play action, with a 72.2% completion rate and 8.7 yards per attempt on those dropbacks. Notably, Love’s excellence on play action is likely correlated with a reduction in pressure rate — he’s pressured roughly five percent less often on play action dropbacks — as Love is more significantly affected by pressure than just about any QB in the league. The Packers QB has a 124.9 passer rating when not pressured (fourth-highest) and a 56.8 passer rating when pressured (fourth-lowest). His negative passer rating differential of -68.1 when pressured versus when he's clean is second-largest among qualified passers, behind only Joe Flacco.
So what can Love and Green Bay expect against the Eagles in Week 10? Well, according to NFL Pro, Philly has had the third-worst pass defense efficiency against play action and is bottom-half of the league in pressure rate this season. However, they made a concerted effort to correct that by acquiring edge rusher Jaelan Phillips at the trade deadline. The former Dolphin has logged a career-high 16.5% pressure rate in 2025 (10th among defenders with 150+ pass rushes) and his 20.0% pressure rate since Week 5 ranks third-highest (minimum 50 pass rushes). He’s also specifically posted a 6.8% quick pressure rate, eighth-highest among that same pass rush sample, which could cause problems for the development of the Packers’ play action game plan.
Fantasy Fallout: The Eagles have not been a soft matchup for quarterbacks, and adding Phillips makes things a little more daunting, but Love and the Packers tend to thrive where Philly has struggled. This makes him a fringe starter in Week 10 and grants a modicum of hope for the well-distributed Green Bay receiving corps.