Third-year defensive end Owa Odighizuwa was suspended for the first four games of the season for violating the league's performance enhancing drugs policy.
The New York Giants announced Tuesday they have parted ways with Odighizuwa.
"It is unfortunate that things have gone in this direction," said general manager Jerry Reese, "but we wish nothing but the best for Owa as we all move forward."
Odighizuwa has tallied just six combined tackles in 18 games played through two seasons with Big Blue.