Tough position to be in: The Colts have never made the playoffs after starting 4-5 or worse in a season.
Luck conquers Titans: Andrew Luck has never lost to the Titans in his career (8-0 record).
Key matchup: Andrew Luck has been sacked more than any QB in the NFL, and the Titans have the most sacks in the NFL over the last six weeks.
Problematic defense: The Colts rank 30th in total defense and 29th in scoring defense.