It's not always how many injuries a team suffers that matters. It's how many they suffer at one particular position.
Potential starter Terrell Thomas is out for the season. His replacement Prince Amukamara was not available for the season opener. Third-round pick Jayron Hosley is getting back up to full strength. Amukamara's replacement Michael Coe got hurt in the second half Wednesday night, forcing Justin Tryon into action. And that's when the Giants secondary really collapsed.
The good news: This is hardly a death sentence for the Giants. They have a long wait until their next game against Tampa Bay, but need to come up with solutions. New York's secondary was very banged up to start last season too, and that worked out pretty well.