Colts offensive lineman Jack Mewhort is retiring from the NFL after just four seasons. He looked like he would become a staple on the interior of the offensive line just two seasons ago but injuries derailed that plan.

More than 2,800 players are going to fight for their football lives in the next month, with some competitions more dire than others. Nick Shook previews a handful of key position battles up front.

The Colts attacked the OL positions heavily in the draft, but they're clearly not done tinkering with the group yet. The Colts signed offensive tackle Austin Howard.

Gregg Rosenthal examines each of the rosters in a rapidly improving AFC South. What's the one remaining question in Jacksonville? Is Houston the biggest boom-or-bust team in the NFL?

Adam Rank is back with a fresh new crop of fantasy football sleepers. A lot has changed with the NFL draft now over, so who is Rank high on? Marlon Mack is among Rank's players to watch.

Daniel Jeremiah identifies five draftees that landed in the perfect place and three picks that left him scratching his head. Plus, Bucky Brooks gives his take on why the Giants are a contender coming out of draft weekend.

The Indianapolis Colts are shelving their starting guard for the remainder of the season. Jack Mewhort was placed on injured reserve on Saturday after aggravating a knee injury.

The Giants, already without receivers Odell Beckham and Brandon Marshall, will now be missing several more starters when they play at Denver on Sunday night. Here is a list of injury updates.

Jalen Ramsey enjoyed a fine rookie season -- and Leonard Fournette could follow suit. Yes, the Jags are loaded -- well, beyond one position. Gregg Rosenthal studies starting lineups across the AFC South.

Bears wide receiver Kevin White is set to make his NFL debut, according to NFL Media Insider Ian Rapoport. The No. 7 pick of the '15 draft missed all of last season with a stress fracture.

Good news: Cheat sheet is back! Here is your guide around the league and everything you need to know as the first Sunday of the NFL regular season kicks off.

Andrew Luck remains steadfast in his belief that the Colts offense will bounce back in 2016. Can he overcome Indianapolis' beleaguered offensive line?

Judy Battista examines the biggest storylines that have cropped up this preseason, including Ezekiel Elliott's resplendent debut, Roberto Aguayo's yips and Joey Bosa's (now-completed) holdout.

The Cowboys will miss Tony Romo, but Dak Prescott's dynamism softens the blow. Meanwhile, the Colts just can't seem to protect Andrew Luck. Gregg Rosenthal reviews the best and worst of Week 3.

San Diego Chargers backup running back Branden Oliver suffered a gruesome looking Achilles injury Sunday against the Minnesota Vikings and won't return to the game.

It's a new year, but the same blocking problems persist for the Indianapolis Colts. Andrew Luck was pressured on more than 50 percent of his dropbacks Saturday night, leading to an early exit.

Trevor Siemian likely did enough to fend off Mark Sanchez and Paxton Lynch in the Broncos' win over the Rams on Saturday night. What else did we learn from the day's preseason games?

Now that the Colts have made Andrew Luck the highest-paid player in NFL history, what's next for a team hoping to get back to the playoffs in 2016? We look at four big questions facing Indianapolis.

The Jacksonville Jaguars made plenty of upgrades to their defense this offseason, but will it be enough to push them into the playoffs? Kevin Patra projects the rosters for the AFC South.

The Rams' big splash to acquire the No. 1 overall pick in the draft dramatically reshapes the top of the first round. Check out Lance Zierlein's adjusted projection following Thursday's massive trade.

Andrew Luck directed the Colts' offense to three fourth-quarter touchdowns, leading his team to a 35-33 comeback over the Titans. Has Indy righted the ship after an 0-2 start?

Marcus Mariota and Johnny Manziel both flashed enticing talent in Week 2, but nobody was more impressive than Melvin Ingram. Bucky Brooks provides grades for notable players on AFC teams.

The Colts announced Sunday they have released right tackle Godser Cherilus. Cherilus struggled with injuries and consistency in two years with Indianapolis.

The Colts made a head-scratching selection when they took Phillip Dorsett in the first round to join a crowded receiving corps. Will the speedy rookie crack the starting lineup?