The knee has been an issue for Tillman since Week 10, when reports surfaced that it was hyperextended. Bill Voth of Black and Blue Review then reported in mid-December that Tillman was dealing with a partially torn ACL.
The 13-year veteran understood the risk of a complete tear, but wanted to continue playing for a dominant Panthers squad that remained undefeated deep into the season.
Tillman's season-ending injury comes just a few weeks after slot corner Bene' Benwikere was placed on injured reserve with a broken leg.
A team that managed to avoid major injuries for four months following Kelvin Benjamin's August ACL tear will now enter the playoffs minus two of its top three cornerbacks.
Here are other injuries we've been following on Monday: