Fox Sports' Jay Glazer first reported the news.
The injury will prevent Johnson from chasing a $2 million incentive that would have triggered with a 1,300-yard season and a trip to the Pro Bowl. He had been on pace for 1,184 rushing yards and 1,268 yards from scrimmage prior to the injury.
Arizona is one of the few teams with the quality depth to withstand such an injury to its leading rusher. The issue is compounded, however, by a turf toe ailment that sent Andre Ellington to the sidelines minutes after Johnson left.
Although the elder Johnson was the talk of the league while averaging 5.9 yards per carry in October, he managed a paltry 3.0 yards per rush in November. One of the NFC West leader's few concerns has been Johnson's lack of punch in short-yardage situations.
It's quite possible that the younger Johnson will prove to be an upgrade in a withering ground attack.