Kamara is officially questionable for Sunday's game due to an ankle injury, the team announced Friday.
NFL Network's Tom Pelissero reported, per a source, that it's not considered a major injury and Kamara sat out Friday's practice as a precaution.
When asked Friday if Kamara was injured this week, New Orleans coach Sean Payton declined to get into specifics.
With quarterback Drew Brees (right thumb) still out, losing Kamara, a dual-threat star back, would be all the more impactful.
Kamara has 101 touches for 583 yards from scrimmage through five games so far.