"I think there is something to winning these types of games," Smith said. "There's a different type of confidence you get when you win games like this."
The Chiefs (6-3) came out on top in a key midseason AFC showdown by improving to 6-1 in their past seven games.
It was a different mood altogether in the Buffalo's locker room after the Bills (5-4) unraveled coming out of their bye week off. McKelvin had difficulty containing his anger in issuing a series of profanity-laced answers in discussing how his fumble helped cost Buffalo the game.
"I take this ... to heart," McKelvin said. "I fumbled the ball. It hurt us. But we still had a chance to come back and win the game. (Stuff) happens in the game. But you've still got to overcome it."
The outcome turned early in the fourth quarter with Buffalo clinging to a 13-10 lead.
Two plays later, Smith faked a handoff to the right to Charles, and then took off left for the go-ahead score with nearly nine minutes left.
Orton went 29 of 48 for 259 yards, including a 25-yard touchdown to Hogan. Marcell Dareus had three of Buffalo's six sacks.
"It's disappointing, it's frustrating, all those words," Chandler said. "I don't know what to say about it. We've got to be better."
Things don't get any easier for the Bills, who had a two-game win streak snapped and fell to 2-4 against conference rivals. They face a key test in a short week - at division rival Miami on Thursday night.
This marked the fourth time during their playoff drought the Bills lost after compiling a 5-3 record. Buffalo hasn't had six or more wins through nine games since 1999, the last time it made the playoffs.
The Chiefs, who opened last season at 9-0, find themselves on another roll and in the thick of a jumbled AFC playoff race.
"It's just crazy how the NFL is going this year," offensive tackle Eric Fisher said. "It was a huge AFC game for us. Getting that win, being 6-3, that sounds pretty good."
Charles finished with 98 yards rushing, Smith went 17 of 29 for 177 yards and Dwayne Bowe had eight catches for 93 years.
NOTES: Chiefs RB Cyrus Gray sustained a torn knee ligament. Reid said TE Demetrius Harris his foot before the game. ... Bills WR Marquise Goodwin did not return after hurting his ribs in fourth quarter. ... Bills RB Fred Jackson was limited to 10 yards rushing and 39 yards receiving in his first game after hurting his groin three week ago.
Copyright 2014 by The Associated Press