NFL Media's Rand Getlin reported on Monday that Shady was unlikely to see the field this week as he deals with a hamstring injury.
The running back didn't practice on Wednesday.
With McCoy likely out this week, bulldozing power back Karlos Williams is slated to carry the bulk of the workload. The fifth-round pick has rushed for 186 yards on 24 totes (7.8 yards per carry) with three touchdowns in three games.
Ryan also said he's not sure if receiver Sammy Watkins will play this week as he deals with a calf injury. The wideout also missed practice on Wednesday.
Here's the rest of Wednesday's injury news:
Rapoport reported that wide receiver Jarius Wright (hand) is "expected to miss a game or two" after not participating in practice.