Appearing on WNDE-AM in Indianapolis, Wayne said Tuesday that he expects to be cleared for football activities on April 25.
The 35-year-old fully expects to be ready for training camp in late July.
"I'm a fan of (Nicks). We can combine all the winning he's done and we've done and come out with a nice mixture," Wayne said. "He's a big target, great skills, big hands ... I really don't think there are a lot of guys that can cover him."
The Colts continue to grow stronger while the rest of the AFC South clubs struggle to find an identity amid quarterback questions and/or new coaching staffs.