The teams have split the last four meetings, but St. Louis leads the all-time regular-season series 60-54-2. Check out the last five matchups here.
Keep your eye on ...
Rams' quarterback situation: Marc Bulger was pulled during the team's loss last week and was benched earlier this season. Coach Jim Haslett, however, said that Bulger is not in danger of losing his job as a starter. But will Bulger be given a quick hook if the team struggles? Bulger has 10 touchdowns and four interceptions in his career against the 49ers.
49ers' focus:Mike Singletary made a huge imprint on the 49ers in his first game as coach in Week 8, pulling quarterback J.T. O'Sullivan and sending enigmatic tight end Vernon Davis to the shower. The 49ers responded with a great effort in Week 10 after the bye week, but fell just short. Will the 49ers continue to receive their old-school coach's message and show improvement?
Did you know?
St. Louis wide receiver Donnie Avery is second among NFC rookies with 25 receptions for 392 yards. ... Rams defensive end Chris Long leads all rookies with four sacks. ... Receiver Isaac Bruce faces his former team for the first time. Bruce is the Rams' all-time leader in receptions (942), receiving yards (14,109) and receiving touchdowns (84).