It was over when ...
The Bills turned the ball over on downs as quarterback J.P. Losman was sacked and threw two incompletions on Buffalo's final possession.
Losman started the second half for the Bills due to a groin injury sustained by starter Trent Edwards. Losman finished 11-of-17 with 93 yards. ... 49ers WR Isaac Bruce's first-quarter touchdown was the 90th of his career. ... San Francisco's win prevented the Arizona Cardinals from clinching the NFC West. ... Bills RB Marshawn Lynch finished with a season-high 134 yards rushing on 16 carries.