Why this game is intriguing: The drama over the NFL's best (or worst?) handshake of 2011 pulls us in. We're weak. Whatever happens after the game, whatever the score, the postgame greeting between 49ers coach Jim Harbaugh and Lions coach Jim Schwartz could be entertaining. Will they nearly come to blows again? Will it involve a back slap? Or, in the heat of the moment, will both of them offer levity? Before all that, though, it's merely a matchup of the NFL's nastiest defense vs. Detroit's pass-first offense.
What to watch: Quarterback Matthew Stafford's comeback took all the headlines, as he shook off a mistake-filled performance to thrive under fire and guide the Lions to a narrow win over the Rams. But under the radar, Detroit actually ran the ball. Kevin Smith averaged 4.8 yards per rush, and if that can continue, it should make their attack much more varied. But will anyone be able to run the ball against Patrick Willis, NaVorro Bowman and company? Doubtful. On offense, San Francisco showcased quite an array of weapons in Week 1, with Randy Moss grabbing a touchdown. Can the Lions make Alex Smith revert to his old ways or is there too much talent around him?