It was over when ...
Trent Edwards hooked up with Lee Evans for a 39-yard touchdown pass to give Buffalo a two-touchdown lead with 10:24 remaining in the fourth quarter.
Game ball
The Rams entered the fourth quarter with a 14-13 lead, but cornerback Jabari Greer's interception for a touchdown on the first play of the quarter turned the momentum in Buffalo's favor.
Key stat
After recording 99 yards and a touchdown on 16 carries in the first half, Rams running back Steven Jackson was limited to just 11 yards on eight carries in the second half.
Noteworthy
The Rams suffered their eighth straight loss, dating to last season. ... Starting in his first game since Week 5 of last season, Rams QB Trent Green went 17-of-32 with 236 yards, no touchdowns and one interception. ... Rams CB Tye Hill sprained his knee in the first quarter and did not return. ... The Bills are 4-0 for the first time since 1992.
