The Carolina victory sets up a huge showdown next Sunday night with New Orleans with first place in the NFC South on the line.
Newton ran for 68 yards and overcame two interceptions. The third-year quarterback has thrown 13 touchdown passes and run for five scores during the Panthers' current win streak.
Carolina's defense, which came in allowing the fewest points in the league, forced two turnovers and sacked rookie Mike Glennon four times to snap a three-game winning streak for Tampa Bay (3-9).
Copyright 2013 by The Associated Press