Newton tied Steve Young's NFL record for most career TDs rushing by a quarterback with 43. Young took 15 seasons to reach that plateau; Newton did it in five.
Newton completed 21 of 26 passes for 293 yards as Carolina (15-1) overcame a slow start to build a 31-3 lead in the third quarter.
Jameis Winston was intercepted twice, and the Bucs (6-10) finished last in the NFC South for the fourth time in five years.
Copyright 2016 by The Associated Press