There is great excitement in the air as we now know when the NFL's games will be played in the 2025 season… all the way from the opener in Philadelphia in early September to Super Bowl 60 in San Francisco in February. With games being played on three different continents in this most historic of all seasons, here are 25 mouth-watering contests that are sure to entertain in the 2025 campaign.
Week 1 Los Angeles Chargers vs Kansas City Chiefs Fri Sep 5, 2025
Hot on the heels of a divisional clash between Philadelphia and Dallas to kick off the 2025 campaign, the Chargers and Chiefs will meet in a big early-season AFC West showdown in Sao Paolo, Brazil. These AFC playoff teams from 2024 should be contenders once more.
Week 1 Baltimore Ravens at Buffalo Bills Sun Sep 7, 2025
The NFL's top two quarterbacks from the 2024 season – Baltimore's Lamar Jackson and Buffalo's Josh Allen – will go head-to-head once again. And revenge will be on the Ravens' minds following their agonising 27-25 defeat in Buffalo in last season's AFC playoffs.
Week 2 Philadelphia Eagles at Kansas City Chiefs Sun Sep 14, 2025
Jalen Hurts and Patrick Mahomes each have a Super Bowl victory against the other. It will be Mahomes who is keenest for revenge at Arrowhead following February's title game hammering at the hands of the Eagles. Will Philadelphia's defense decide matters again?
Week 3 Detroit Lions at Baltimore Ravens Mon Sep 22, 2025
The last time Jared Goff and the Lions played in Baltimore they were on the wrong end of a 38-6 drubbing in 2023. Detroit have done nothing but grow in stature since then and this could be an early peek at a potential Super Bowl matchup. Both teams have that goal in mind.
Week 4 Pittsburgh Steelers vs Minnesota Vikings Sun Sep 28, 2025
One of the most anticipated and emotional games of 2025 will take place at Dublin's Croke Park in the first regular season contest in Ireland. With the Irish fans desperate for this game and travelling support from the United States, this atmosphere will be off the charts!
Week 5 Cleveland Browns vs Minnesota Vikings Sun Oct 5, 2025
A milestone moment for the NFL in the United Kingdom as the Browns-Vikings contest will be the 40th regular season game to be played in London. The Browns will be playing an international game for just the second time in their history. The Vikings are going back-to-back in Dublin and London.
Week 6 New York Jets vs Denver Broncos Sun Oct 12, 2025
The NFL returns to Tottenham Hotspur with Aaron Glenn's Jets looking to find some early-season momentum with a victory against a talented Denver team that made the playoffs under Sean Payton in 2025. Will Justin Fields shine for the Jets or will Bo Nix put on a show?
Week 6 Chicago Bears at Washington Commanders Sun Oct 12, 2025
They're only in their second seasons but the top two picks in the 2024 NFL Draft – Chicago's Caleb Williams and Washington's Jayden Daniels – are on to chapter two of their rivalry. Daniels won the first meeting with a memorable Hail Mary touchdown last year.
Week 7 Jacksonville Jaguars vs Los Angeles Rams Sun Oct 19, 2025
The Jaguars return to their spiritual home of Wembley Stadium as they play a regular season game internationally for a record 14th time – all of them in London. This contest will give British fans a first look at rookie two-way sensation Travis Hunter.
Week 7 Philadelphia Eagles at Minnesota Vikings Sun Oct 19, 2025
In what could be a mid-season dress rehearsal for the NFC Championship Game, both quarterbacks will face stern tests against very good defense. The Vikings will look to confuse Jalen Hurts, while the Eagles will be all about pressuring first-year starter J.J. McCarthy.
Week 8 Green Bay Packers at Pittsburgh Steelers Sun Oct 26, 2025
This only takes on real relevance if Aaron Rodgers signs with the Steelers and Pittsburgh are competitive by the time we roll into Week 8. If both hold true, how weird is it going to be to see Rodgers firing passes against the Packers? If only this game had been scheduled for Lambeau.
Week 9 Denver Broncos at Houston Texans Sun Nov 2, 2025
Two AFC playoff teams from a year ago will be led by exciting quarterbacks looking to take a leap in 2025. Bo Nix led the Broncos to the playoffs as a rookie and is after more than a first-round exit this time around. C.J. Stroud has taken Houston to the final eight but now wants to delve deeper into the postseason.
Week 9 Kansas City Chiefs at Buffalo Bills Sun Nov 2, 2025
The latest chapter in the Patrick Mahomes-Josh Allen saga will take place in western New York. Allen is 4-1 in the regular season, Mahomes a perfect 4-0 in their playoff meetings. Both teams are genuine contenders in the AFC once again and could meet twice this season.
Week 10 Indianapolis Colts vs Atlanta Falcons Sun Nov 9, 2025
With NFL games having already been played in Munich and Frankfurt, it will be Berlin's turn to take centre stage in Germany. The Colts – led by either Anthony Richardson or Daniel Jones at QB – will clash with the Michael Penix-led Atlanta Falcons at the historic Olympic Stadium.
Week 10 Los Angeles Rams at San Francisco 49ers Sun Nov 9, 2025
The Rams reached the final eight in the race to last year's Super Bowl and with Davante Adams joining an offense led by Matthew Stafford, they are ready to contend again. Despite a poor 2024 campaign, the San Francisco 49ers could be their biggest challengers out west.
Week 11 Miami Dolphins vs Washington Commanders Sun Nov 16, 2025
There will be more history made in Week 11 as the Miami Dolphins take on the Washington Commanders in the first regular season game to be played in Spain. Madrid's dazzling Bernabeau Stadium – home to Real Madrid – will provide the stunning backdrop for the clash between Tua Tagovailoa and Jayden Daniels.
Week 13 Green Bay Packers at Detroit Lions Thurs Nov 27, 2025
The NFL is not messing around with its Thanksgiving Day schedule this year and starting off this most American of all holidays will be the traditional contest in Detroit. And the Lions – who have genuine Super Bowl aspirations – will face another NFC contender in the Packers.
Week 13 Cincinnati Bengals at Baltimore Ravens Thurs Nov 27, 2025
After the Dallas Cowboys have hosted the Kansas City Chiefs, the Thanksgiving nightcap game will be an absolute cracker from the AFC North. There are likely to be plenty of points scored in this one as Cincinnati's Joe Burrow and Baltimore's Lamar Jackson trade blows.
Week 13 Seattle Seahawks at Minnesota Vikings Sun Nov 30, 2025
This one may not immediately jump off the page, but the Seahawks have designs on being a playoff team after their 10 wins a year ago and they will be led by Sam Darnold. The QB who resurrected his career with the Vikings will square off against his replacement, J.J. McCarthy.
Week 14 Chicago Bears at Green Bay Packers Sun Dec 7, 2025
These oldest of NFL rivals will meet twice in December and this first matchup at Lambeau Field could power a late-season run to the playoffs. This game features exciting playmakers at quarterback in Chicago's Caleb Williams and Jordan Love, of the Packers.
Week 14 Cincinnati Bengals at Buffalo Bills Sun Dec 7, 2025
How about an early Christmas present in the form of two of the NFL's most exciting quarterbacks going toe to toe? As we enter the home straight in the race to the AFC playoffs, Joe Burrow and Josh Allen are going to be pivotal to the chances of their respective teams.
Week 15 Atlanta Falcons at Tampa Bay Buccaneers Thurs Dec 11, 2025
The NFC South could be up for grabs when these division rivals meet in Florida in December. The Falcons have high hopes in their first full season with Michael Penix Jr. at the helm, while the Bucs – led by Baker Mayfield – will be chasing a fifth straight division title.
Week 17 Dallas Cowboys at Washington Commanders Thurs Dec 25, 2025
Washington should be in the thick of the NFC playoff race with Jayden Daniels at the helm. If the offensive trio of Dak Prescott, CeeDee Lamb and George Pickens is firing on all cylinders, perhaps the Cowboys could join them? That would make this a massive contest.
Week 17 Denver Broncos at Kansas City Chiefs Thurs Dec 25, 2025
Even if you cast aside their late-season drubbing of the Chiefs' backups for one moment, Denver proved to be a thorn in Kansas City's side in 2024; almost winning at Arrowhead as well. Could this be a Christmas classic and a defining moment in the Sean Payton-Box Nix era?
Week 18 Indianapolis Colts at Houston Texans TBD
This regular season finale could decide the destination of the AFC South crown. Will C.J. Stroud and the Texans take the division for the third year in a row or will the Colts rise up? And which quarterback will lead Indy by this stage of the season? Anthony Richardson or Daniel Jones?
