The Cleveland Browns announced Thursday the No. 1 overall pick would not travel overseas with the team.
Garrett went into concussion protocol on Wednesday after the rookie complained Tuesday of concussion-like symptoms.
Sunday's absence will mark the fifth missed game for the first-round pick, who dealt with an ankle injury and sat out the first four games of the 2017 campaign.
News of Garrett's absence is a blow to the Browns hopes of capturing their elusive first win of the season. Despite missing more games than he's played, when on the field Garrett looks like the real-deal pass-rusher scouts promised he'd become in the NFL.
In just three games, Garrett leads Cleveland in sacks (4) and has at least one sack in each of his games played.