The Eagles had three takeaways, sacked Manning three times and forced two intentional grounding penalties.
"All the credit goes to them," Bradford said of Philadelphia's defense. "It seemed like every time we needed a stop or a big play, they created a lot of turnovers tonight. That always gives us a lot of momentum and always gives us juice."
"We were stagnant," Giants coach Tom Coughlin said. "They did more with their opportunities than we did."
Neither team looked sharp in front of a prime-time audience. They combined for seven turnovers and 21 penalties.
"That's bad football," Coughlin said.
Wearing all-black uniforms for the third time in franchise history, the Eagles got off to another slow start.
Manning completed his first 10 passes, including a 13-yard TD pass to Odell Beckham Jr. for a 7-0 lead.
But things went downhill for Manning from there.
"Terrible read by me, bad decision to make that throw," Manning said. "I should have gone to my next guys in my progression."
Murray had his best game since joining the Eagles after a record-breaking season in Dallas. The All-Pro led the NFL in rushing last year and broke Emmitt Smith's single-season club record, but has struggled in Philadelphia. He entered the game with 130 yards this season.
"We know we have a long way to go," Murray said.
Bradford had a pair of third-quarter interceptions on poor throws, including one that Landon Collins picked in the end zone.
But Philadelphia's defense bailed him out.
"We need to improve on offense," coach Chip Kelly said.
The Giants came out playing Kelly's style of football, running a no-huddle offense. They moved right down the field and Manning connected with Beckham across the middle for a score.
Copyright 2015 by The Associated Press