McCoy was listed as questionable after leaving practice early on Wednesday with hamstring tightness. Shady missed practice Thursday and was limited Friday.
Expect McCoy's snaps to be limited in Miami. Shady has played 75.8 percent of Bills snaps through six games, an average of 47.5 per contest -- that number could be cut in half.
McCoy sits second in the NFL in rushing yards with 587. He also ranks second with six rushing TDs and 5.6 yards per carry. Shady sparked the Bills' four-game win streak with shifty runs into the second level.