Coach Mike McCarthy took a wait-and-see approach on Friday with his veteran receiver.
"We'll see what today brings. It's unfortunate, but we'll see how it goes," he said.
The receiver is officially listed as questionable on the injury report.
Cobb has participated in 91 percent of the Packers' offensive snaps through three games, corralling 17 catches for 194 yards and a TD. The past two games, however, the No. 2 receiver has been slowed, generating just eight catches for 52 yards.
If Cobb can't go Sunday versus the Buffalo Bills, the onus would fall to Geronimo Allison and rookies Marquez Valdes-Scantling and Equanimeous St. Brown to pick up the slack behind No. 1 target Davante Adams. The Packers could also take a tight-end heavy approach with Jimmy Graham, Lance Kendricks and Marcedes Lewis.
Here are the other injuries we're monitoring ahead of Sunday's Week 4 contests:
- Philadelphia Eagles running back Jay Ajayi (back) good to go for Sunday, coach Doug Pederson said. Safety Rodney McLeod underwent knee surgery, but no determination has been made on whether they will place him on injured reserve, Pederson said. Eagles wide receiver Alshon Jeffery is dealing with an illness, and it remains unclear whether he'll make his season debut this week. He is listed as questionable. Running back Darren Sproles will not play this week due to a hamstring injury.
- Seattle SeahawksDoug Baldwin (knee) is listed as questionable for Sunday against the Arizona Cardinals, but coach Pete Carroll said the veteran wide receiver will play. Running back Chris Carson (hip) and defensive end Dion Jordan (hip) are questionable and running back C.J. Prosise (abdomen) is doubtful. Defensive end Rasheem Green (ankle) and linebacker K.J. Wright (knee) are out.
- New York Jets linebacker Josh Martin (concussion) and wide receiver Terrelle Pryor (ankle/groin) both will play Sunday. Safety Marcus Maye (ankle/foot), cornerback Buster Skrine (knee), safety Doug Middleton (knee/finger) are all listed as questionable and game-time decisions. Tight end Neal Sterling (concussion) and wide receiver Charone Peake (hamstring) will not play.
Giants running back Jonathan Stewart was placed on injured reserve with a foot injury, the team announced Friday.
- Chicago Bears cornerback Prince Amukamara (hamstring), wide receiver Anthony Miller (shoulder) and cornerback Marcus Cooper (hamstring) have all been ruled out.
- Indianapolis Colts running back Marlon Mack (hamstring) is listed as questionable. While tackle Anthony Castonzo (hamstring) has been ruled out. Defensive lineman Denico Autry (ankle) and safety Malik Hooker (hip/groin) both have been removed from the injury report.
- Tennessee Titans quarterback Marcus Mariota (right elbow) and tackle Jack Conklin (knee) have been removed from the injury report. Quarterback Blaine Gabbert (concussion) did not practice this week and is listed as questionable. Tackle Dennis Kelly (illness) and running back David Fluellen (groin) will not play.
- Detroit Lions wide receiver Golden Tate was limited in practice because of a hip injury and is questionable to play against the Dallas Cowboys. Defensive end Ezekiel Ansah (shoulder) was ruled out after not practicing all week and guard T.J. Lang is off the injury report. Linebacker Jarrad Davis (knee) is questionable after a limited practice session.
- New Orleans Saints rookie defensive end Marcus Davenport (hip) is questionable to play against the New York Giants after being limited in practice. Linebacker Manti Teo (knee) won't play because of a hip injury. Running back Alvin Kamara (knee) was limited in practice Friday, but he was not listed on the injury report for the game.
- Oakland Raiders defensive tackle P.J. Hall is questionable to play against the Cleveland Browns because of an ankle injury after being limited in practice all week. Offensive tackle Donald Penn is off the injury report and cornerback Dominique Rodgers-Cromartie (hamstring) is questionable after being limited in practice.