Giants coach Tom Coughlin said Friday that Tuck has been ruled out of Sunday's game against the Buffalo Bills, as was expected. Tuck has missed the last two games with neck and groin injuries and has yet to practice this week. Jacobs missed his third straight day of practice Friday, according to The Star-Ledger, which would appear to end his chances of playing. Jacobs sat out last week's loss to the Seahawks with a sprained medial collateral ligament in his left knee.
Linebacker Nick Barnett (ankle) was also limited, while defensive tackle Kyle Williams (foot) did not practice for the third straight day. Both are questionable, and Williams is expected to be a game-time decision. Linebacker Chris Kelsay (calf) and wide receiver Donald Jones (ankle) were ruled out.
The Associated Press contributed to this report