"Yeah, that's what we do," Spiller said. "The only thing I was thinking was, 'Man, what we could've done if we played together in college.'"
The injury looked serious, though coach Joe Philbin had no update on Moreno's status following the game.
The Bills provided electricity to a charged-up crowd during a week the franchise celebrated its proud past and promising future.
The game began with a tribute to Hall of Fame owner Ralph Wilson, who died in March. And it came during an uplifting week in which the franchise's long-term future was essentially secured: Wilson's trust reached a "definitive agreement" to sell the team to NHL Buffalo Sabres owners Terry and Kim Pegula for an NFL-record $1.4 billion.
"It was one of the most special days of my career," Brandon said. "A great tribute to Ralph on Friday, and then to cap it off today with a tremendous win, and the pregame ceremony. It doesn't get any better."
Spiller struck first on the ensuing kickoff by bursting through a hole up the right hash mark. Kelvin Sheppard was the only Dolphin to get his hand on Spiller, who had a clear path to the end zone once Sturgis missed a diving tackle at the Buffalo 35.
Watkins finished with eight catches for 117 yards, and Spiller added 69 yards rushing.
Manuel went 16 of 26 for 202 yards in building on his promising performance in a season-opening 23-20 overtime win at Chicago.
Very little went right for the Dolphins' offense, which failed to carry over momentum from last weekend's 33-20 win over New England. The big blow came when Moreno was hurt on his first carry. Driving up the middle for a 4-yard gain, Moreno was initially hit on the right side by Nickell Robey. Nigel Bradham then struck Moreno from the left, hitting him directly in the arm.
Moreno, with Denver last season, had an NFL-leading 134 yards rushing entering Week 2.
"Obviously, we would love to have him, but you have to deal with those things," Philbin said. "Injuries happen, so it didn't really impact the game plan a whole lot. Other guys have to step up."
The Dolphins were limited to six first downs and 62 yards offense in the opening half, and never advanced past their 41.
"We just didn't play well. We didn't get first downs," Tannehill said. "We didn't rush the ball. We didn't throw the ball. We didn't catch the ball. We didn't do anything well."
NOTES: The Dolphins have lost three straight to Buffalo, their longest losing streak since going 0-4 from 2006-07. ... Carpenter hit five of six field goal attempts, the longest from 38 yards. He hit the left crossbar on a 31-yarder. ... DEs Mario Williams and Jerry Hughes, and DTs Kyle Williams and Stefan Charles each had a sack.
Copyright 2014 by The Associated Press