It was Mayfield's ninth game this season with at least two passing TDs.
Unlike Manning and Wilson, Mayfield did not start all 16 games in order to achieve this record. He started 13 games after taking over for an injured Tyrod Taylor just before halftime in Week 3.
Cleveland's offense turned around almost immediately upon the insertion of Mayfield in that game, a 21-17 win over the New York Jets, hit a lull before Hue Jackson was fired, and then reached its peak once offensive coordinator Freddie Kitchens took over playcalling. Mayfield flourished under Kitchens, tossing 19 of his 27 touchdowns after Week 8.
Mayfield completed 23 of 42 passes for 376 yards, three touchdowns and three interceptions against the league's No. 1 defense on Sunday night.