The team announced that the NFL has suspended Simpson six games for violating the league's policy and program for substances of abuse. Simpson can return to the active roster on October 19, the day after the team's Week 6 matchup against the Baltimore Ravens.
"The probability of a suspension was known when we signed Jerome," general manager Trent Baalke said in a statement released by the team. "Since joining the 49ers, Jerome has proven to be a great teammate."
Simpson's off-the-field issues occurred during his time with the Minnesota Vikings. The team released the veteran wide receiver last September after learning of a July arrest on charges of driving on a limited driver's license, possession of marijuana in a motor vehicle and open bottle in a motor vehicle.