Nightmare matchup for newly anointed Browns starter Jason Campbell, tasked with marching into raucous Arrowhead to face a dominant Chiefs defense. Kansas City's league-leading 35 sacks are 10 more than the Ravens, who are second on that list. Edge rushers Tamba Hali and Justin Houston get all the attention, but offensive lines have their hands full with ascendant nose tackle Dontari Poe.
Eli Manning is on pace for 34 interceptions, which -- if he sinks that far -- would be the third-most in NFL history behind George Blanda (42 in 1962) and Vinny Testaverde (35 in 1988). One of his star receivers hasn't helped: Pro Football Focus credits Manning with a passer rating of 100.5 on throws to Victor Cruz, but that sinks to 59.0 on passes aimed at Hakeem Nicks.
Miami's struggling offensive line is a core reason the Dolphins are mired in a three-game losing streak. After the trade for left tackle Bryant McKinnie, Jonathan Martin will move to the right side, and tackle Tyson Clabo will move to the bench. Clabo's 7.5 sacks allowed are the most in the NFL, and Martin's six rank fifth on that list. McKinnie, at best, is a stopgap.
The Jaguars don't figure to derail a 49ers offense that's off and running. Creative coordinator Greg Roman has leaned heavily on Frank Gore and the power ground game during a four-game win streak. We saw a heavier dose of Colin Kaepernick running out of the pistol last week, and we'll be watching to see if the 49ers keep this trend going.
Where would the Bills be if C.J. Spiller were playing up to expectations? Last year's most dazzling young rusher just has one 100-yard outing this season and two games with fewer than 15 yards. After running for six yards a clip in 2012, he's accomplished that feat in just two tilts in 2013.
We're tired of the Romo bashing. He owns the highest career fourth-quarter passer rating since 1991 and has thrown a touchdown in 20 straight games. Romo is especially good against Detroit of late, throwing for 300-plus yards and two or more scores in his last three games against the Lions. Let's see if Detroit linebacker DeAndre Levy -- tied for a league-leading four picks -- can slow old Tony down.
The Bengals have won four of five games, with every win coming down to the last possession. The Jets' defense will keep this game close, and there's no chance the Bengals will be able to run on Damon "Big Snacks" Harrison and crew. The Jets are looking to win back-to-back games for the first time this season.
This game is a matchup of strength on strength and weakness on weakness. Despite injuries to Roddy White and Julio Jones, the Falcons offense is humming. But their offensive line is going to struggle to hold off Calais Campbell and company. Meanwhile, Carson Palmer finally might have found an opposing pass rush that can't touch him.
Peyton Manning's arm looked weak on Sunday because his ankle was hurt, and the Indianapolis Colts kept moving him "off the spot" with pressure. The Redskins have the pass rushers on the outside to give Denver problems, but Washington does not have the cornerbacks to play press coverage against the Broncos.
Christian Ponder is expected to start this game for Josh Freeman, who suffered a concussion against the New York Giants. The change at quarterback can't possibly hurt Minnesota. Ponder actually had a career high 6.9 yards-per-attempt before he was hurt, which isn't that far below league average.
Zac Stacy has been a bright light in an otherwise grim offensive season for the Rams. He's powerful and very comfortable in the passing game. He bounces off tacklers and can block. A true three-down running back, Stacy looks like a young, poor man's Frank Gore.