A loss would give Buffalo nine defeats on the season, which would be the ninth straight year with a losing record. The Rams have the second longest streak in the NFL with six straight losing seasons.
Quietly one of the finest games of the week. Can Nick Foles maintain his white-hot streak of 19 touchdowns to zero interceptions? He set an Eagles record with 233 consecutive passes without a pick, but Detroit linebacker DeAndre Levy -- tied for the league lead with six interceptions -- might have something to say about that.
Schein: Shape up or ship out
As we venture into the final quarter of the regular season, Adam Schein identifies nine players with everything to prove. READ
Michael Floyd looks like a true No. 1 receiver, but the Cardinals offense is hard to rely on because of Carson Palmer. He missed a ton of open throws last week that could have resulted in a win in Philadelphia. That's the bad news. The good news: Arizona has outgained its opponents nine times this year, including five times in a row.
While the Kansas City defense completely collapsed last month, the offense has been remarkably good. Alex Smith has pushed the ball down the field more, helping Kansas City to average more yards per game than any team in the NFL in November.
When the Chargers lose, they don't lose by much. Their average margin of defeat is 5.86, the third-lowest in the NFL. Three of their losses have come in the last 15 seconds.
The Seahawks have outscored the 49ers 71-16 in their last two meetings, but both of those games were in Seattle. San Francisco's offense has quietly rounded into form the last two weeks with long, sustained drives. Don't expect many passes in this game; these are the two most run-heavy teams in the league.
Cam Newton has been far more effective throwing to his left this year. His passer rating is 112.2 to the left, 93.4 up the middle and 65.3 to the right. Carolina's station-to-station offense has the longest average scoring drive this season. The big plays are gone.