"Certainly it's a blow," offensive coordinator Greg Roman said Saturday, per the San Jose Mercury News. "He's looked so good and was back to form."
If Hunter is gone for the season, the 49ers will lean on Hyde and might not have the luxury of keeping Lattimore on the NFI list when the season starts. LaMichael James remains on the roster and could also see increased time as the change-of-pace back -- a role he played when Hunter was out with an Achilles tear in 2012.
At the end of the day, however, Gore will still shoulder the load in San Francisco.