This was the game where the Patriots-Colts mystique first started to take shape. The Patriots built up a 31-10 lead early in the third quarter, but -- as we came to learn in subsequent meetings -- no lead is safe in this rivalry. Late in the fourth quarter, the Colts trailed 38-34 with the ball at the Patriots' goal line. On fourth down, Willie McGinest -- who injured his knee earlier in the drive (this is debatable) -- darted through the line to bury Edgerrin James, saving the Patriots in the process.
The nadir of Manning's career (that doesn't involve multiple neck surgeries). A four-interception meltdown that swung public opinion in the "Brady or Manning?" debate. After the loss, then-Colts president Bill Polian -- upset with the Patriots' hyper-physical secondary play -- pleaded with the NFL's Competition Committee to better enforce defensive holding and illegal contact. The league agreed with Polian, a decision that continues to have huge ramifications on the sport.