The team announced it placed both defensive end Shaq Lawson (ankle) and receiver Jordan Matthews (knee) on injured reserve.
Losing two key players for the rest of the season is just another blow for the Bills, who have dropped four of their last five games and are on the outside looking in on the AFC playoff picture.
Matthews, meanwhile, tried to play through a knee injury the past few weeks, but concluded his season with just 25 catches as a Bill. He's slated to be a free agent this offseason.
Here are other injuries we're tracking Tuesday:
- The Chicago Bears placed Kyle Long on IR with a shoulder injury. The big offensive lineman was also battling ankle and finger ailments.
- The Houston Texans placed wideout Bruce Ellington and tight end C.J. Fiedorowicz on IR. This is the second time this season Fiedorowicz has been on IR for a concussion.