In terms of travel schedules this season, Harbaugh has it a little easier than his younger brother Jim, whose San Francisco 49ers will travel across to the east coast twice (they play at the New York Jets and New England Patriots) in 2012. As shown by Football Freakonomics in April, both Harbaughs are open to the idea that a players' body clock can have an impact on his performance.
According to Cold Hard Football Facts, the four teams from the west coast have a 32-57 record in 10 a.m. PST starts over the past five seasons. Five of those wins were by the 49ers in 2011.
Given the overwhelming evidence that teams from the west coast are at a competitive disadvantage when traveling east, and that scientific studies shows that an athlete's performance is at its peak late in the afternoon, the NFL should accommodate these west coast teams by scheduling games in the the Eastern Time Zone for the late afternoon time slot on Sundays.