According to a Louisiana State Police news release, Jackson crashed into a car moving across lanes on U.S. Highway 51 in Tangipahoa, Louisiana, around 1 a.m. CDT.
The driver of the car, a 20-year-old woman, was reversing out of a parking space before the vehicle backed across lanes on the highway. Jackson was travelling "at a high rate of speed" when he hit the driver's side door and penetrated the vehicle. The driver of the car also was killed in the collision.
Police are continuing to investigate the crash and blood samples from the scene were taken for analysis.
Jackson, a teammate of Brett Favre's at Southern Mississippi, was selected by the Browns in the sixth round of the 1991 NFL Draft. He played eight NFL seasons, staying with the team when it relocated to Baltimore. He finished with more than 700 receiving yards in three of his first five seasons and posted career highs in receptions (76), yards (1,201) and touchdowns (14 -- tied for most in league) in 1996.
Jackson tallied 5,393 receiving yards and 46 touchdowns before retiring at age 29. He served as the mayor of the Village of Tangipahoa from 2009-12.