Hopkins began the game with a pair of diving catches, burned Titans cornerbacks for a pair of long touchdowns and racked up nearly 100 yards after the catch, just missing two more scores inside the 5-yard line.
The performance was so complete that it earned Hopkins the highest single-game wide-receiver grade ever handed out by analytics site Pro Football Focus.
NFL Media analyst Mike Mayock dissected Hopkins' attributes this week on NFL NOW's Mayock Slants, pointing out the former Clemson star's naturally strong hands, development as a route runner, adjustment at the point of the catch and a determination to score every time he touches the ball.
Mayock also pointed out that it helps to have Andre Johnson drawing double coverage, but believes Hopkins has reached the point where the two receivers are helping each other.
"I'm just happy to see the kid grow as a player," Johnson said this week, via ESPN.com. "Comparing this year to last year, it's amazing. It's fun to watch. I'm glad I can be here and just see it. I'm very happy for him. Just to see him grow and I know he is going to continue to get better and better. I wish I could have had him earlier in my career."
With four games left to play, Hopkins has already joined Johnson as the only receivers in franchise history to generate more than 1,000 yards in a season. He's now on pace to finish with 80 receptions, 1,388 yards and eight touchdowns, while surpassing Johnson as the team's most dangerous playmaker.