The corner will do pre-rehab and have surgery in a few weeks, per Rapoport.
Harris left the game midway through the third quarter and did not return.
There is a chance that, facing Brady, Denver could move veteran cornerback Champ Bailey back outside after starting him at nickel back.
In their first meeting against the Patriots, the Broncos' defense broke down after the first half when Dominique Rodgers-Cromartie injured himself on a Hail Mary in the second quarter and missed the rest of the contest. This time, the Broncos will face Brady for an entire game without one their top cornerbacks.