Joe Mixon played through an ailing foot last week. It will sideline him entirely this week.
The Bengals running back was unable to practice for the third straight day and has been ruled out of Sunday's game against the Browns, coach Zac Taylor said.
Mixon got off to a fast start in Week 6 as Cincinnati built a 20-point lead. But a second-quarter injury derailed his effectiveness and, ultimately, the Bengals' upset bid. The loss was already Cincy's third by one possession this season. The second came to Cleveland in Week 2.
If the Bengals are going to avenge the latter defeat, they'll have to do it without their star back. Mixon is averaging just 3.6 yards per carry but is by far the team's leading rusher. He's also first in touchdowns and fourth in receiving.
Wide receiver John Ross is questionable after not practicing this week because of an illness.
Here is other injury and roster news we're tracking on Friday:
- Green Bay Packers running back Aaron Jones suffered a mild calf strain in practice Thursday, NFL Network's Tom Pelissero reported. While the fourth-year back told reporters he's "confident" he can play Sunday versus the Texans, Pelissero noted he'll likely be a game-time decision. He's officially listed as questionable, as are linebacker Preston Smith (shoulder) and tight end Robert Tonyan (ankle). Offensive tackle David Bakhtiari (chest) is doubtful
- Dallas Cowboys guard Zack Martin won't play Sunday versus Washington after recently suffering a concussion, per coach Mike McCarthy.
- The Pittsburgh Steelers released veteran punter Dustin Colquitt and placed linebacker Devin Bush on injured reserve.
- San Francisco 49ers coach Kyle Shanahan said he is optimistic offensive tackle Trent Williams, who's been battling an ankle injury, will be able to play Sunday versus the Patriots. He's listed as questionable. Linebacker Kwon Alexander (ankle), running back Raheem Mostert (ankle) and safeties Jaquiski Tartt (groin) and Jimmie Ward (quadricep) are ruled out.
- New York Jets coach Adam Gase said, barring any setbacks, quarterback Sam Darnold (shoulder) and left tackle Mekhi Becton (shoulder) will play Sunday against the Bills.
- Cleveland Browns coach Kevin Stefanski said tight end Austin Hooper will not play Sunday versus the Bengals because he has appendicitis. Hooper had an appendectomy Friday and could miss next week's game versus the Raiders as well, NFL Network Insider Ian Rapoport reported. Quarterback Baker Mayfield (chest), wide receiver Jarvis Landry (hip, ribs) and running back Kareem Hunt (ribs) do not have a game designation. Safety Karl Joseph (hamstring) is questionable.
- An MRI for Philadelphia Eagles wide receiver DeSean Jackson confirmed his ankle injury will sideline him indefinitely, per Rapoport. Philly will place Jackson on injured reserve but there's a chance he returns this season, Rapoport added. Offensive tackle Lane Johnson suffered a grade 1 MCL sprain Thursday night but isn't expected to miss much time because of it, per Rapoport. Coach Doug Peterson said Johnson, who's also dealing with an ankle injury, is day to day. Defensive tackle Hassan Ridgeway will miss the rest of the season with a biceps injury, per Pederson.
- New York Giants running back Saquon Barkley is scheduled for ACL reconstruction surgery next week and doctors are hopeful he will be ready for training camp, NFL Network's Andrea Kremer reported. Barkley tore his ACL in Week 1 but had to hold off on the procedure until his MCL healed. Respected surgeon Dr. Neal ElAttrache of Kerlan-Jobe in Los Angeles will do the procedure, per Rapoport. The Giants also traded linebacker Markus Golden to the Cardinals in exchange for a 2021 sixth-round pick.
- Washington Football Team offensive lineman Saahdiq Charles (knee) and wide receiver Antonio Gandy-Golden (hamstring) have been ruled out for Sunday's game against the Cowboys.
- The Chicago Bears made three moves involving their practice squad, activating offensive lineman Badara Traore from the reserve/COVID-19 list, signing safety and special teams ace Marqui Christian and releasing linebacker Sharif Finch.
- The Carolina Panthers activated kicker Joey Slye and offensive lineman Trent Scott from the reserve/COVID-19 list and placed cornerback Rasul Douglas on it. Cornerback Eli Apple (hamstring), guard John Miller (ankle), cornerback Donte Jackson (toe), and wide receiver Curtis Samuel (knee) are all questionable for Sunday against the Saints. The team also officially signed safety Sean Chandler off the Giants practice squad.
- Kansas City Chiefs wide receiver Sammy Watkins (hamstring) and offensive tackle Mitchell Schwartz (back) have eben ruled out for Sunday versus the Broncos.
- Buffalo Bills cornerback Josh Norman (hamstring), guard Cody Ford (knee), wide receiver John Brown (knee), tight end Dawson Knox (calf) and linebacker Tyrel Dodson have been ruled out for Sunday against the Jets. Linebacker Matt Milano (pectoral), cornerback Tre'Davious White (back) and cornerback Cam Lewis (wrist) are questionable.
- Atlanta Falcons defensive end Takkarist McKinley (groin) is questionable for Sunday's game versus the Lions.
- Jacksonville Jaguars linebacker Myles Jack (ankle), tight end Tyler Eifert (neck) and safety Jarrod Wilson (hamstring) are out for Sunday's game against the Chargers.
- New Orleans wide receiver Emmanuel Sanders has been placed on the reserve/COVID-19 list and thus will not play Sunday versus the Panthers, per Rapoport. Wide receiver Michael Thomas, who suffered a hamstring injury in practice earlier this week, did not practice Friday and is considered a long shot to play, Rapoport reported.
- Lions cornerback Desmond Trufant (hamstring) has been ruled out for Sunday against the Falcons. Detroit is hosting former Ravens running back Alex Collins, per Pelissero. The 26-year-old veteran is fully healthy after breaking his leg last season, Pelissero added.
- Los Angeles Chargers guard Trai Turner (groin) has been ruled out for Sunday's game against the Jaguars. Right tackle Bryan Bulaga (back), running back Justin Jackson (knee) and quarterback Tyrod Taylor are questionable. Wide receiver Keenan Allen (back), who was limited in practice this week, has been removed form the injury report. Coach Anthony Lynn said defensive end Melvin Ingram, who's been out with a knee injury, will be a game-time decision.