Kyle Shanahan's 49ers are in the midst of a season in which they're encountering incredibly unfortunate amounts of injuries, but he's not pointing to the two reserve lists -- injured and COVID-19 -- with fingers of blame.

Bobby Turner has played an instrumental role in some of the most impressive rushing performances of the last 25 NFL seasons. Former personnel executive Scott Pioli draws from his experience as a colleague of Turner's to provide insight on why the 49ers' RBs coach has had so much success developing unheralded players into some of the biggest NFL stars, including Hall of Famer Terrell Davis.

49ers coach Kyle Shanahan announced Monday that running back Raheem Mostert sustained a high ankle sprain in the team's Week 6 win 24-16 win over the Rams and is "most likely" headed to injured reserve.

Gregg Rosenthal spies teams that faced a Week 6 fork in the road. Did D'Andre Swift's Lions turn toward the light? Are Kirk Cousins' Vikings bound for darkness?

Week 4's in the books. So ... what's hot and what's not? Marc Sessler has his finger on the NFL pulse, and this dispatch opens with a magical moment for one long-suffering fan base.

Is there any rushing duo better than the Browns' Nick Chubb and Kareem Hunt? Nick Shook lists the NFL's top 10 backfields.

Dual-threat quarterbacks are off to a hot start in 2020. Maurice Jones-Drew divides these multi-talented QBs into five tiers. Plus, there's a new No. 1 in his top-15 running back rankings.

Niners running back Tevin Coleman's knee injury is expected to have him sidelined for about four weeks, coach Kyle Shanahan said. Tight end George Kittle returned to practice.

The 49ers might have finally gotten some good news involving its MRI machine. Raheem Mostert's latest tests revealed an MCL sprain, leaving the team optimistic its lead back won't be out for an extended period, Tom Pelissero reports.

Fresh off the second Sunday of the NFL's 2020 season, Adam Schein spotlights developments he loved (SEE: Josh Allen silencing critics), liked (Arizona hitting 2-0) and loathed (another Falcons face-plant).

San Francisco defensive end Nick Bosa was carted off Sunday with what is likely a torn ACL. He wasn't the only 49ers player to be knocked out.

Maurice Jones-Drew makes a plea to NFL offensive coordinators to utilize running backs in the passing game more often. Plus, there's a new player in his ranking of the top 15 RBs.

Who will lead the NFL in rushing in 2020? Maurice Jones-Drew makes his prediction. Plus, he ranks his top 15 running backs heading into Week 1. 

Raheem Mostert requested a trade over the offseason, but after ironing things out in regards to his current contract, the 49ers running back reflected on how things materialized. 

The San Francisco 49ers smoothed everything out with Raheem Mostert. The running back finalized a new deal with the Niners on Monday, according to the running back's agent, Brett Tessler.

Are the 49ers still the class of the NFC West? Is the Seahawks' O-line cause for concern? Adam Maya examines all four of the division's teams ahead of training camp, identifying position battles, strengths and weaknesses for each.

Running back Raheem Mostert spoke to a high-ranking member of the 49ers' organization to clear the air and get on the same page moving forward after he made a trade request.

With Patrick Mahomes now under contract through the 2031 season, is Kansas City about to embark on a dynastic run? Bucky Brooks provides a four-part plan for the Chiefs to maximize their returns. Plus, the top five players in the NFL today.

49ers running back Raheem Mostert has requested a trade, NFL Network Insider Ian Rapoport reported Wednesday afternoon. 

Injuries have sidelined Jerick McKinnon since he joined the 49ers two years ago. In his quest to get back on the field, the RB is planning to work out with former teammate Adrian Peterson.

Will Odell Beckham Jr. get the last laugh in his first meeting against the team that traded him away? Dan Hanzus runs down 10 of the juiciest revenge matchups on the 2020 NFL schedule.

Chris Wesseling assesses the landscape of NFL offenses now that the draft has concluded and the majority of free-agent signings are in the books. Which units are the most potent? Here are the top 10 attacks heading into the 2020 season.

The 49ers got some much-needed salary relief and the Dolphins got some much-needed backfield aid, as San Francisco shipped RB Matt Breida to Miami for a fifth-round pick on Saturday.

Michael Fabiano ranks the top 25 fantasy running backs based on a combination of rushing attempts and receptions and the positive points that resulted in 2019.

From the anniversary of Nick Foles' return to the Eagles that ended in a Super Bowl win to the anniversary of the Saints signing Drew Brees, check out some of this week's historic NFL people and moments. Think you know your football trivia? NFL Research looks back at some of the great games, stunning accomplishments and historic people to keep you in the loop on this day in history.

Watch all of the highlights from the San Francisco 49ers and Los Angeles Rams in their Week 12 divisional matchup in the 2020 NFL regular season.

San Francisco 49ers running back Raheem Mostert hits paydirt on 49ers' 75-yard drive with untouched touchdown.

NFL Network's Tom Pelissero reports that the San Francisco 49ers have designated running backs Raheem Mostert and Jeff Wilson Jr. for return from injured reserve.

Next Gen Stats ranks the top 10 runs from the first half of the 2020 season by rush yards over expected.

The top 15 highest scoring fantasy plays at the midway point of the 2020 NFL season.

Highlighting the plays that featured the most yards after the catch through Week 9 of the 2020 NFL season.

Ranking the fastest ball carriers of the 2020 NFL season Weeks 1-9 by miles per hour as provided by Next Gen Stats.

Relive the top five plays from the San Francisco 49ers' first half of the NFL season.

The "Good Morning Football" crew crowns the Week 6 angry runs winner.

Watch the highlights from the Week 6 matchup between the Los Angeles Rams and the San Francisco 49ers.

San Francisco 49ers running back Raheem Mostert nearly carries three Rams defenders for first down.

Here is every player with a Pro Football Focus grade of 90 or above in Week 5 of the 2020 NFL season.

Watch the top plays from Week 5 during the 2020 NFL season.

Watch the game highlights of the Week 5 matchup between the Miami Dolphins and the San Francisco 49ers.

San Francisco 49ers running back Raheem Mostert makes an 11-yard run.

San Francisco 49ers running back Raheem Mostert makes a 37-yard run.

The Top 5 longest plays from scrimmage of the first quarter of the 2020 season

Take a look back at the most surprising yards after-catch plays through Week 4 of the 2020 NFL season using Next Gen Stats.

Next Gen Stats ranks the Top 5 rush yards over expected from first quarter of the 2020 NFL season.

Watch the top 15 fantasy plays from first quarter of the 2020 NFL season.

Next Gen Stats ranks the fastest ball carriers of the season so far by miles per hour.

Check out the top rushes from the NFL during September of the 2020 season.

Watch the best plays from the San Francisco 49ers in the month of September.

NFL Network's Tom Pelissero explains how the San Francisco 49ers are adapting to injuries to quarterback Jimmy Garoppolo, tight end George Kittle, running back Raheem Mostert.

Around The NFL's Nick Shook discusses his Top 10 running back rooms in NFL through two weeks.