"He's ready to go," McCarthy told reporters. "He's back to his old self. He was punchy as hell at practice. He's ready."
Grant had started the first three games of the season and is second to James Starks on Green Bay with 157 rushing yards on 32 carries.
Linebacker Clay Matthews (quadricep), cornerback Charles Woodson (foot, knee) and right tackle Bryan Bulaga (knee) didn't practice for the second consecutive day, but wide receiver Donald Driver (shin) and left tackle Chad Clifton (knee) fully participated as the Packers prepare for Sunday's game against the Atlanta Falcons.