"He's been in a couple of tough arenas -- going into Pittsburgh for his first game, that's about as tough as it gets," Mangini said.
McCoy will get the call because neither Jake Delhomme nor Seneca Wallace was able to practice all week as they recover from high ankle sprains.
"I think Seneca has a shot this week (to be active), but it's an outside shot," Mangini said.
Wallace hasn't played since injuring his ankle Oct. 10 against the Atlanta Falcons, his fourth consecutive start filling in for Delhomme, who rolled his ankle in the season opener at Tampa Bay. High-ankle sprains typically take four to six weeks to heal, and Wallace is just one month into recovery.
Starting tackle John St. Clair (ankle) also didn't practice Friday. Mangini held out hope that all three injured players could return soon.
"We just follow what the trainers and doctors say," Mangini said. "The week he (Wallace), John and Jake had was the best they've had in terms of movement."
The Associated Press contributed to this report.