The Dolphins confirmed the death of Mandich, who also was a star at Michigan. He was diagnosed with bile-duct cancer in early 2010, but continued to work on game broadcasts last season.
Besides working as a color commentator for most of the past 20 seasons, Mandich hosted a radio call-in show and luncheons for the Dolphins Touchdown Club.
"I was sad to hear about Jim's passing," said Hall of Fame head coach Don Shula, who coached Mandich from 1970 to 1977. "I always looked at him as a guy who was bright, well prepared and competitive. He was someone who I could count on as a player and was instrumental in the success we had during his time with the Dolphins."
Mandich won a wide following for his unabashed support for the home team and his signature call "All right, Miami!" But he also was candid in his criticism, such as when Bill Parcells gave up control of football operations before last season.
"He was a hired gun. He was a personality," Mandich said. "He came in; he leaves two years later. I feel like taking Listerine and washing my mouth out, because it doesn't feel good to me."
Before being drafted in Shula's first year with the Dolphins in 1970, Mandich was a Michigan captain in 1969, leading the Wolverines to a Big Ten Conference co-championship and an appearance in the Rose Bowl. He was a first-team All-American and was inducted into the College Football Hall of Fame in 2004.
"I've played in a perfect season and in Super Bowls," Mandich said in 2008. "But I'm proudest of playing for the maize and blue."
Funeral arrangements hadn't been announced as of late Tuesday.
Copyright 2011 by The Associated Press