James Anderson already has 53 tackles.
(Nell Redmond / Associated Press)
The storyline
Once it looked to be a meeting of winless teams; then the 49ers went and beat Oakland last week. Now it's a must-win for San Francisco if it is to recover from an 0-5 start.
Why you should watch
Matt Moore being back under center for Carolina after a horrendous start to season could mean plenty of turnovers.
Did you know?
Niners RB Frank Gore leads the NFC with 755 yards from scrimmage. ... San Francisco's Vernon Davis has scored a TD in three straight games. ... When Jonathan Stewart has at least 14 carries, the Panthers are 14-0. ... Carolina's Charles Godfrey leads the NFL in interceptions with four.
